Magic™ Membrane Protein Human CCR1 (C-C motif chemokine receptor 1) (CAT#: MP0006F)

Datasheet

The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). These chemokines and their receptor mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. CCR1-C-C Chemokine Receptor type 1-is one of the most prevalent targets for drug development according to the distribution of patents for small molecule inhibitors of chemokine receptors.

Product Specifications

Host Species
Human

Target Protein
CCR1

Protein Length
Full Length

Protein Class
GPCR class A

Molecular Weight
41 kDa

Sequence
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF

Product Description

Activity
To be tested

Application
Screening & display technologies, Antibody development, Structural Biology

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>50% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
CCR1

Full Name
C-C motif chemokine receptor 1

Introduction
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Alternative Names
CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Gene ID
1230

UniProt ID
P32246

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Q&As

What is the role of CCR1 in cancer?

CCR1 is overexpressed in several types of cancers, such as hepatocellular carcinoma and breast cancer, and is associated with increased immunosuppressive cell infiltration and metastasis.
2022-12-09

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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